They are the shortest-priced team for the drop with West Ham not far behind at 1-2.
Wolves thrashed fellow strugglers Blackpool 4-0 and move to 10-11 with the Seasiders drifting to 2-1, leapfrogging West Brom (6-5) in the betting.
Blackburn have slipped back into trouble and are cut to 6-1 with Everton out to 25-1 having been a short as 14-1 in recent weeks.
Alex Donohue of Ladbrokes said: “Wigan and West Ham are the sides that look in the most danger at the prices as Wolves pull away.
“Blackburn have experienced the most dramatic odds cut change as their safety looks far from guaranteed.”