It's an easier task for the Blues who should see off Marseille at home with plenty to spare but the Gunners will have to fight hard to beat Partizan Belgrade away.
Both sides started their campaign with big wins and I'm looking at a London double tonight.
Chelsea will be determined to floor the French after seeing their 100 per cent record ended by Man City.
Didier Drogba struggled at Eastlands before being taken off and it could be an equally famous Le Sulk, Nicolas Anelka, who does the damage against his countrymen.
Arsenal's price isn't too attractive at 8-11 with Chandler and although they should win a bet on both sides to score at 4-6 with Betfred is the call.
The Gunners have lost keper Manuel Almunia to an elbow and he joins Cesc Fabregas, Robin van Persie, Nicklas Bendtner, Thomas Vermaelen and Theo Walcott on the sidelines.
Arsenal's problem has been keeping clean sheets although their 6-0 defeat of Braga suggests they can stil turn it on when it's required on the European stage.
Real Madrid were another side disappointed at the weekend as they were held by Levante but Jose Mourinho's side, almost certain to keep a clean sheet in Auxerre, can edge out the French. They are a best 8-13 with Hills.
Roma could be the best bets of the night after kickstarting their season with a win against Inter Milan at the weekend. They are 4-9 with 888sport to beat Cluj at home.
AC Milan and Bayern Munich face tricky trips to Ajax and Basel respectively. Both could be draws especially if Bayern are without Franck Ribery and Arjen Robben.
Both teams to score is also the call when Braga entertain Shakhtar Donetsk and bookies expect Spartak Moscow to beat Zilina at home but a best price of 1-2 with Hills looks a bit skinny.
Paddy Power are offering 22-1 that none of the four English teams win their respective Champions League matches this week.
With none of the Premier League’s clubs formerly known as “The Big Four” winning in the league for the first time since December 2008 and Spurs also failing to collect any points the English teams all go into this week's round of Champions League matches in indifferent form.
However, it’s more likely at 6-1 they all get back to winning ways while four draws pays
In the Championship it's difficult to ignore Cardiff at home to George Burley's rock bottom Crystal Palace.
Palace were hammered 5-0 at Derby at the weekend while the Welsh added their third home win in four outings. Cardiff are 4-7 with the likes of Hills and totesport.
Derby can repeat their succes at home to Gordon Strachan's Middlesbrough and are a tempting 7-5 with Blue Square and Hills.
Watford cruised to victory against Boro and could do the same against Swansea. Malky Mackay's side are 13-10 with Hills.
And in League Two Rotherham should be too hot at home to a Bradford side who have again disappointed their huge support this season. They are 3-4 with 888sport.
- Derby (7-5, Skybet)
- Klose to score v Basel (15-8, Stan James)