Holders Arsenal are 7-1 across the board ahead of a trip to the seaside to tackle Brighton and Liverpool now face Bolton at Anfield after edging out Wimbledon last night.
Spurs are 16-1 ahead of their replay with Burnley while Everton are 20-1 before facing West Ham tonight.
Southampton, 33-1 at BetVictor, could be a decent each-way bet but they must win their replay at Ipswich the see off Palace at home.
If you're looking for a shock it could come at Aston Villa who entertain Championship leaders Bournemouth while Rochdale have been rewarded with a home tie against Stoke after seeing off Nottm Forest.
Derby should get through against Scunthorpe or Chesterfield and are 7-2 with BetVictor to be the Football League side that goes furthest in the tournament.
4th Rd draw
Southampton/Ipswich v Crystal Palace
Cambridge United v Manchester United
Blackburn v Swansea
Chelsea v Millwall/Bradford
Derby v Scunthorpe/Chesterfield
Preston v Sheffield United
Birmingham v West Brom
Aston Villa v Bournemouth
Cardiff v Reading
Liverpool v Bolton
Burnley/Tottenham v Leicester
Brighton v Arsenal
Rochdale v Stoke
Sunderland v Fulham/Wolves
Doncaster/Bristol City v Everton/West Ham
Manchester City v Middlesbrough
Ties to be played across the weekend beginning January 24.