All four home teams won last week so Arsenal, Atletico Madrid, Leipzig and Lazio take leads into the second legs.
Arsenal stormed into a 4-1 half-time lead against CSKA Moscow and that's how it finished. Twenty-six teams have lost a Europa League knockout by three goals and only one (Valencia) have overturned the deficit.
But the Gunners will be aware Roma achieved the feat on Tuesday and Juventus almost repeated it the next night in Madrid.
CSKA have lost at home to Man United, Basel and Lyon and if Arsene Wenger needed a win I reckon he'd get it. But he doesn't and the away looks a bit skinny at 27-25 with Marathonbet.
Not sure where value is here as both to score is also short at 4-7 with betfair.
So the bet could be Alexandre Lacazette to score at 16-11 with Unibet. He netted a double in the first leg and will again play instead of cup-tied Pierre-Emerick Aubameyang.
There could be another Roman conquest as Lazio take a 4-2 lead to Red Bull Salzburg. The first leg was a thriller and there could be plenty of goals in Austria with the home going on the front foot.
Lazio are in good form and could win again at 28-13 with Unibet but like Arsenal don't nee the victory. Lazio draw no bet could be worth a look at 32-25 and I like over 2.5 match goals at 8-13 with betfair.
The tie that's most finely balanced is Marseille v Leipzig. The Germans won 1-0 at home and know an away could be enough to see them through.
They lost 4-1 at home to Bayer on Monday but maybe had one eye on this tie and away from Germany they've have won at Napoli, drew in St Petersburg and beaten Monaco.
Midfield ace Naby Keita is a doubt and will be a big miss if he doesn't start but Leipzig should score and qualify. Not to lose they are 13-20 at Marathonbet and I also expect both to score.
I don't see any problems for Atletico Madrid as they head to Sporting Lisbon with a two-goal safely tucked away.
Sporting's defeat in Spain was heavily criticised by club president Bruno de Carvalho and he even suggested Bas Dost and defender Fabio Coentrao got booked on purpose.
De Carvalho threatened to ban the whole squad but a deal was brokered and full-strength Sporting beat Pacos 1-0 at the weekend.
Dost and Coentrao will be missed and it's open to question if Sporting can test seriously good opponents.
Atletico will push for an away goal and I'm on Antoine Griezmann – 16 goals in 15 goals – to get it at 13-8 with boylesports.
- Lacazette to score
- Lazio draw no bet
- Leipzig +1
- Griezmann to score