Union Saint-Gilloise and Marseille both sit on six points after five Champions League game so this clash in Belgium could prove pivotal to their hopes of reaching the knockout stages.
The Belgians are sitting at Europe's top table for the first time and got their campaign off to a brilliant start with a 3-1 win away to PSV Eindhoven.
Heavy defeats to Newcastle, Inter Milan and Atletico Madrid brought them crashing back down to earth but Union responded with a surprise 1-0 win away to Galatasaray that bust my coupon.
Marseille also revived their European campaign in the last round of fixtures, winning 2-1 at home to Newcastle after back-to-back defeats against Sporting and Atalanta.
Both their Champions League wins have come in front of a frenzied crowd at the Velodrome but Roberto De Zerbi's men now have to find a way to win on the road.
Their hopes of toppling PSG in Ligue 1 have suffered a blow, with Marseille taking just a point from their last two domestic games against Toulouse and Lille.
De Zerbi will be looking to bounce back in Europe and so will Union boss David Hubert after losing to Anderlecht and drawing with Gent in their last two matches.
How the bookies view it: Marseille with the egde
This is a tricky one to call with both teams in similar form but Marseille are favourites at a best 11/8 with Betway. Union Saint-Gilloise are as big as 2/1 with BetMGM while the draw pays 5/2 with most firms.
Head to head: Union seeking spirit of the 60s
You have to go all the way back to 1962 for the only previous meeting of these sides. That came in the Fairs Cup and Union Saint-Gilloise won 4-2 in Belgium to overturn a 1-0 deficit from the first leg.
Players to watch: Plenty of Promise
Promise David netted Union's winner in Istanbul and should lead the line once more. The Canadian is 19/10 with BetMGM to take his tally for the season to double figures.
Veteran Pierre-Emerick Aubayemang stepped up for Marseille against Newcastle, with two brilliant finishes turning the game on its head. The former Arsenal star sits on 12 goals for the season and is 13/8 at Bet365 to add to that tally.
Backed a player to find the net? Check our Goalscorer Betting guide to see how the markets work and where to find value.
Probable line-ups
Pierre-Emile Hojbjerg is a doubt for Marseille due to illness while Amine Gouiri, Hamed Traore, Ruben Blanco and Facundo Medina are set to miss out.
The Belgians have a cleaner bill of health with only Mohammed Fuseini on the sidelines.
Union Saint-Gilloise: Scherpe, Mac Allister, Burgess, Leysen, Rasmussen, Van de Perre, Zorgane, Niang, Khalaili, El Hadj, David.
Marseille: Rulli, Balerdi, Pavard, Vermeeren, Weah, O'Reilly, Emerson, Bakola, Greenwood, Paixao, Aubameyang
Anything else catch the eye?
Both teams probably need a win to stand a chance of reaching the knockout stages as they have tough fixtures in the last two rounds of games.
That should make this match a decent spectacle so combining BTTS and over 2.5 goals stands a good chance at 17/20 with William Hill.
With both teams likely to play on the front foot we should see plenty of corners too and over 10.5 flag kicks pays 27/20 at BetMGM.
Most goals have come after the break in the last two Champions League matches for both sides so that bet could also pay off here at 21/20 with Unibet.
GambleAware