Fiorentina are looking to reach the UEFA Conference League Final for the third year in a row but will have to brave a Spanish storm in the first leg of their semi-final with Real Betis.
Having finished runners-up to West Ham and Olympiakos in the last two years, the Serie A club are desperate to go all the way this term and get their hands on the trophy.
Chelsea, who face Djurgardens in the other semi, are massive favourites to win the tournament but whoever comes out on top in this clash will fancy their chances in the showpiece.
Real Betis head into the game in slightly better form, with a 5-1 spanking of Valladolid last Thursday making it just one defeat in their last 13 games in all competitions.
But Fiorentina are also flying and Sunday's 2-1 win over Empoli made it eight games unbeaten for La Viola as they look to finish with a flourish.
So the stage is set for what should be an entertaining and intriguing semi-final, with this first leg in Spain likely to set the tone for the tie.
How the bookies view it: Banking on Betis
This looks like a 50/50 tie to me but BoyleSports make Real Betis their 4/6 favourites to reach the final, with Fiorentina the 23/20 outsiders. For a first leg win in Spain, the La Liga side are just 6/10, with La Viola 4/1 and the draw priced 11/4.
Head to head: Real good at Italian jobs
These sides have never faced off in Europe before but Betis' first-ever tie in Europe was a 3-2 aggregate win over Milan in the 1978/79 Cup Winners' Cup. They have since faced Italian opposition six more times, losing only once – to Bologna in the 1998/99 UEFA Cup.
Players to watch: Isco in the groove
Real Betis playmaker Isco has 11 for the season, his best tally for the last eight years, and has scored in his last two games so his confidence will be up for this one. The former Real Madrid star is 11/5 at Paddy Power for anytime scorer and evens at Bet365 to score or assist.
Midfielder Rolando Mandragora has been a Conference League talisman for Fiorentina this term, chipping in with five goals. He also scored in their last Serie A outing and is a bit ovepriced at 7/1 with Bet365 for another goal here.
Probable line-ups
Cedric Bakambu has netted seven times in Europe this season, more than any player in Betis' history in a single campaign, but has missed their last two games and is set to be sidelined again for this one. Marc Roca, Diego Llorente, Nobel Mendy and Chimy Avila are also set to miss out.
Fiorentina could be without striker Moises Kean due to a personal problem but manager Raffaele Palladino was hopeful of having him back involved. Edoardo Bove, Andrea Colpan and Dodo are set to be sidelined.
Real Betis: Adria, Bartra, Natan, R Rodriguez, Sabaly, Cardoso, Antony, Fornals, Isco, J Rodriguez., Hernandez.
Fiorentina: De Gea, Pongracic, Ranieri, Comuzzo, Mandragora, Cataldi, Fagioli, Gosens, Folorunsho, Gudmundsson, Kean.
Anything else catch the eye?
The bookies make Fiorentina outsiders in Spain but they've won 10 Conference League games away from home in the last three years, more than any other side. That could make them worth a punt in the double chance at 5/4 with BoyleSports.
We should see goals at both ends in this one, with BTTS landing in Fiorentina's last five Euro ties and in the last four in all competitions for Betis. Backing both teams to score pays just 3/4 with BoyleSports but adding on over 2.5 goals boosts the odds to 13/10.
There's not much between these sides so I'd imagine it will be a close game, with the half-time draw paying 23/20. Things can often get spicy when Italian and Spanish sides face off so it could pay to back a lot of cards or booking points when those markets are priced up.
This UEFA Europa League Conference match between Real Betis and Fiorentina will be played on and kick off at 20:00. Check below for our tipsters best Real Betis vs Fiorentina prediction. You may also visit our dedicated betting previews section for the most up to date previews.
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