Chelsea and Tottenham Hotspur both went into the international break on a Premier League downer so they'll be desperate to bounce back with a win in this intriguing London derby.
The league season has effectively been written off for Spurs, with all their eggs in the Europa League basket ahead of a quarter-final clash with Eintracht Frankfurt later this month.
Despite sitting in the bottom half of the Premier League, Ange Postecoglou's side are favourites to get their hands on the Europa trophy, a success that would secure them a ticket to next season's Champions League.
Chelsea are on track to secure their seat at Europe's top table via their league position, while Enzo Maresca's men are also red-hot fancies to win the UEFA Conference League this season.
A top-four finish looks like the tougher assignment with so many teams jostling for position in the top half of the table and the Blues lost 1-0 at Arsenal in their last outing.
Spurs also lost away to Fulham just before the international and now both teams have another London derby to tackle as they bid to get back to winning ways.
How the bookies view it: Blue is the colour
Tottenham Hotspur are 10/3 outsiders for this one, which isn't a great surprise given how poor their league form has been. Chelsea are 8/13 hot favourites and the draw pays 10/3.
Recent head to head: A sweet 16 for Chelsea
Chelsea have dominated this fixture in recent years, with the Blues losing just one of the last 16 meetings. Maresca's side came from 2-0 down to beat Spurs 4-3 in a thriller earlier this season and Chelsea won 2-0 when Postecoglou's side came to Stamford Bridge last season.
Players to watch: Enzo on a high
Enzo Fernandez will have his tail up for this game, having scored for Argentina in their 4-1 World Cup qualifying win over bitter rivals Brazil. That made it six for the season for the midfielder and he's 8/5 at William Hill to score or assist. He is the only player to create five or more chances in four Premier League games this season so that price looks decent value.
Spurs will be hoping star striker Dominic Solanke can stay fit until the end of the season and go on a scoring run. The former Bournemouth striker is on 11 goals for the season and is 5/2 at BoyleSports for anytime scorer.
Probable line-ups
Chelsea trio Nicolas Jackson, Cole Palmer and Noni Madueke are back in training after injuries and could return to the squad. Marc Guiu and Omar Kellyman will miss out again.
Tottenham's long injury list has cleared up a bit but they still have Radu Draguisn sidelined while Kevin Danso, Lucas Bergvall, Dejan Kulusevski and Richarlison are doubts.
Chelsea: Sanchez, James, Colwill, Fofana, Cucurella, Caicedo, Fernandez, Palmer, Neto, Sancho, Nkunku.
Tottenham Hotspur: Vicario, Spence, Van de Ven, Romero, Udogie, Sarr, Bentancur, Maddison, Son, Johnson, Solanke.
Anything else catch the eye?
Chelsea just love playing against Spurs, chalking up more wins against their London rivals (36) than any other team in their Premier League history and also scoring the most goals (120). But they've been a bit flat of late and have netted just two times in their last three outings.
So I would be surprised if we saw a repeat of the 4-3 thriller from earlier this season and combining under 3.5 goals with under 13.5 corners pays 13/10 in a BoyleSports bet builder.
Even with most of their big players back from injury, Spurs continue to struggle and they've won just once in their last five outings. They've also lost eight times on the road in the Premier League, with only the bottom two crashing more times on their travels. So the Blues should edge this one and combining the home win with under 4.5 goals pays 7/5 at BoyleSports.
This fixture often boils over so it could be a busy night for the officials. Crisitan Romero was sent off against Chelsea last term and is often prone to rash challenges. The Argentina stopper is 23/10 to go into the book here.
This English Premier League match between Chelsea and Tottenham Hotspur will be played on and kick off at 20:00. Check below for our tipsters best Chelsea vs Tottenham Hotspur prediction. You may also visit our dedicated betting previews section for the most up to date previews.
GambleAware