Lazio topped the table in the revamped UEFA Europa League so the Italian giants will be confident of seeing off Czech side Viktoria Plzen to book their place in the quarter-finals.
Marco Baroni's men were a cut above most of their opponents in the league phase and their only defeat came away to Braga in the final match after they had already qualified for the last 16.
Even though Lazio have been looking so slick in Europe, it's Spurs who remain favourites to lift the trophy and you can back the Serie A side at a tasty 6/1 to go all the way.
It would be a surprise if they slipped up against Viktoria Plzen but the Czechs were competitive in the league phase and lost just two of their eight matches.
Those defeats came against Manchester United and Athletic Bilbao, who are both the same price as Lazio in the outright betting, so Baroni's side can't afford to show any complacency across the two legs.
With Lazio in the fight for a top-four finish in Serie A, Baroni will be looking to finish the job early against Plzen so I'd imagine he will field a strong side.
How the bookies view it: Lazio in the box seat
It's no surprise to see Lazio as BoyleSports' 2/11 favourites to reach the quarter-finals and they're also just 4/5 for a first-leg win away from home.
Plzen are 11/4 for a victory on home soil and the price increases to 7/2 if you back them to qualify. The first-leg stalemate pays 13/5.
Head to head: No Czech mate
These sides have never faced off in Europe but Lazio have taken on Czech opposition six times. All those games came against Sparta Prague and it couldn't have been tighter, with two draws, two wins, two defeats, seven goals scored and seven goals conceded.
Players to watch: Perfect Dia
Boulaye Dia should lead the line for Lazio and the Senegalese striker is having a decent season, with his tally sitting at 11. He's 15/8 for anytime scorer and that looks decent value.
Pavel Sulc heads into this tie in high spirits after netting twice in his last three outings. The Plzen forward is 3/1 for another goal here and that also looks a bit generous.
Probable line-ups
Cheick Souare and Christopher Kabongo are on the sidelines for Viktoria Plzen and should miss out again.
Lazio are set to be without Taty Castellanos, Elseid Hysaj and Fisayo Dele-Bashiru agains while Alessio Romagnoli is a doubt after missing the weekend win over AC Milan.
Viktoria Plzen: Jedlicka, Markovic, Jemelka, Dweh, Cerv, Cadu, Kalvach, Memic, Vydra, Durosinmi, Sulc.
Lazio: Provedel, Gigot, Tavares, Gila, Lazzari, Rovell, Guendouzi, Zaccagni, Isaksen, Dia, Pedro.
Anything else catch the eye?
Viktoria Plzen have drawn a blank just twice in 14 Europa League games this season so we should see goals at both ends in this one. BTTS pays just 7/10 with BoyleSports but the odds increase to 6/5 if you add on over 2.5 goals. Combining BTTS with no draw boosts the price to 8/5.
Sampson Dweh has been pretty good value for cards this season, with the Plzen defender picking up seven yellows and a red. He's 3/1 for a card in this one at Bet365 and that looks a decent price based on his stats.
Plzen won eight corners at home to Ferencvaros in the play-off round but they racked up just 14 across their eight games in the league phase. That suggests under 8.5 match corners stands a chance at 7/5 with BoyleSports but I'm more drawn to the 23/20 on offer for Lazio -1.5 in the corner handicap.
This UEFA Europa League match between Viktoria Plzen and Lazio will be played on and kick off at 20:00. Check below for our tipsters best Viktoria Plzen vs Lazio prediction. You may also visit our dedicated betting previews section for the most up to date previews.
