Man Utd will take on Lyon in the Europa League on Thursday, 17 April with a place in the semi-finals of the competition up for grabs.
The first leg in France last week finished 2-2 after a late equaliser from Rayan Cherki denied the English side a hard-fought away victory.
Both teams come into the second leg safe in the knowledge that it's win or bust with neither side in contention for any other silverware this season.
How the bookies view it: Man Utd go in as favourites
Man Utd did enough last week to deserve a victory and the bookies have acknowledged that by pricing them as the odds-on favourites to win on Thursday night. BoyleSports have priced a home win at 4/6 while a victory for Lyon has been priced at 3/1. The draw, which would send the tie to extra time, has been priced at 14/5.
Head to head: A repeat of what happened in 2008?
Prior to last week, the last time these two teams met in a competitive tie was in 2008 when they faced off in a Champions League round of 16.
Back then, Karim Benzema led the line for Lyon while Man Utd had a front three of Carlos Tevez, Cristiano Ronaldo and Wayne Rooney. The first leg in France finished 1-1 before Man Utd got the job done 1-0 at home. Could the away draw, home win combination prove to be fruitful for the Red Devils once again?
Players to watch: Who will play in goal for the hosts?
Andre Onana's performance in Lyon was bad enough in isolation but when you consider he had spent the build-up to the match claiming that Man Utd were far superior to Lyon and goading Nemanja Matic, it was an all-time disasterclass.
Onana's performance in France saw Altay Bayindir earn a rare start in between the sticks at the weekend but the Turkish shot-stopper didn't fare any better. He conceded four goals to Newcastle with the fourth goal of the afternoon his fault entirely.
With both goalkeepers looking way below the required standard, Ruben Amorim has a huge decision to make. The safest call would be to recall Andre Onana but given how error-prone the former Inter Milan goalkeeper is, it could be a decision that quite easily comes back to haunt him.
There is a third option for Amorim in the form of Tom Heaton. The vastly experienced goalkeeper has been a reliable and safe, if not spectacular, pair of hands throughout his career and he could see the Red Devils through to the end of the season.
Predicted line-ups
Joshua Zirkzee picked up a hamstring injury at the end of the match with Newcastle and he joins Matthijs de Ligt, Amad Diallo, Ayden Heaven, Jonny Evans, Toby Collyer and Lisandro Martinez on the sidelines for this one. Lyon are likely to go into the second leg unchanged.
Man Utd: Onana – Dalot, Mazraoui, Maguire, Yoro, Dorgu – Ugarte, Casemiro – Fernandes, Garnacho – Hojlund
Lyon: Perri – Maitland-Niles, Mata, Niakhate, Tagliafico – Tolisso, Vererout, Akouokou – Almada, Cherki, Mikautadze
Anything else catch the eye?
Don't be fooled by Man Utd's incompetence in the Premier League as they have proven already this season that they are a different team in Europe. They have scored over 1.5 goals in each of their last two European matches and they are priced at 6/10 to do the same again on Thursday.
This UEFA Europa League match between Man United and Lyon will be played on and kick off at 20:00. Check below for our tipsters best Man United vs Lyon prediction. You may also visit our dedicated betting previews section for the most up to date previews.
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