JUVENTUS travel to Napoli in Serie A's game of the day with the leaders' 1-1 draw at Inter Milan on Tuesday being their third draw in last four league games.
The result kept Juve at the top of the standings but just one point ahead of Roma. Juve haven't won at Napoli in Serie A since the 2000-01 campaign and last month lost to Rafael Benitez's side in a penalty shootout in the Supercoppa final in Doha.
Napoli have lost just once at home this season and are fourth in the standings, level on 30 points with Lazio, who are third.
It looks a tough game to call and draw could be the best way to go considering Juve's recent run of form.
Roma host red-hot Lazio in the Eternal City derby knowing if results go their way they could lead the standings heading into the next round of games.
Lazio have won three of their last four league games to climb to third in the standings, nine points adrift of their city rivals but again a stalemate wouldn't be a surprise.
Genoa have mustered just one point from their last three league games and square off against Inter at San Siro knowing anything but a win could see their city rivals Sampdoria leapfrog them into fifth place. Samp are level on 27 points with Genoa and take on Empoli at the Stadio Luigi Ferraris.
Palermo are riding a nine-game unbeaten run heading into their game against Fiorentina in Tuscany.
Parma make the journey to Verona to face Verona hoping that Tuesday's 1-0 triumph over Fiorentina will spark his team's miserable season into life. The win was Parma's first since November 1 and their third overall.
Chievo will look to extend their good run of form on the road when they meet Atalanta in Bergamo this weekend. The Flying Donkeys have won their last two away games, keeping two clean sheets in the process.
Bottom-side Cesena have not tasted victory since August 31 but despite their poor run of form the Seahorses will fancy their chances of taking at least a point at the Stadio Sant'Elia with opponents Cagliari winless at home this season.