WEST HAM haven't suffered defeat since the last time a team from Manchester came calling and they will be delighted it's United paying them a visit this time.
Champions City inflicted a 5-0 thrashing on the opening day of the Premier League and the Hammers' home record against Pep Guardiola's men is the stuff of nightmares.
It has been 5-0, 4-0, 4-1, 4-0 and 5-0 on City's last five visits, a stunning aggregate score of 22-1, but they have fared far better against the red half of Manchester in London.
United have triumphed just once in four away days against the Hammers and last year's fixture ended in a 3-1 victory for Manuel Pellegrini's men.
With United struggling for form and without a few key players, it bodes well for West Ham and I think the home side are overpriced at a 12/5 with Betfred for a win.
Ole Gunnar Solskjaer's men are coming off the back of a Europa League game but the United boss rested almost his entire team for that 1-0 victory over Astana and the only player who will keep his place is probably Marcus Rashford.
Fatigue shouldn't be a problem for the Red Devils but Solskjaer will be more concerned about his side's lack of punch in attack.
Since opening the season with an impressive 4-0 home win over Chelsea, United have found goals hard to come by, scoring just once in every game since then.
It has been enough to secure them victories in their last two games but that lack of firepower has led to dropped points against Wolves, Crystal Palace and Southampton.
Injuries to Paul Pogba and Anthony Martial have robbed United of some spark up front and Rashford seems to be struggling for form.
He hasn't scored from open play since that opening win over Chelsea and Solskjaer probably started him against Astana in the hope he would bag a few goals to boost his confidence.
That didn't happen though and it took a strike from teenager Mason Greenwood to secure a 1-0 victory. Solskjaer admitted after the game if the kid kept scoring he would find it hard to drop him so it looks like Greenwood will get another start at West Ham.
The youngster is 23/10 with Paddy Power for anytime scorer and that looks a good option if Solskjaer does indeed keep faith with him.
For the Hammers, Sebastian Haller is always a threat, even though the Frenchman let me down when I tipped him to score at Aston Villa last time out. This time, I'll be going with Andriy Yarmolenko as the winger will probably start on the right against a weak link in Ashley Young.
The Ukrainian is a big threat when he cuts in from that flank on to his left foot and I fancy him for anytime scorer at 3/1 with Paddy Power.
West Ham are almost at full strength, although left-back Arthur Masuaku is suspended after his red card at Villa Park while Michail Antonio and Winston Reid are injured.
Games between these sides have traditionally been feisty affairs but that hasn't been the case in the last three encounters, with none of those matches seeing over 2.5 cards. That makes under 3.5 cards appealing in this meeting at evens with Bet365.
This English Premier League match between West Ham and Manchester United will be played on Sep 22, 2019 and kick off at 14:00. Check below for our tipsters best West Ham vs Manchester United prediction. You may also visit our dedicated betting previews section for the most up to date previews.