St Louis City play host to Orlando City on Wednesday evening sitting in 14th place in the Western Conference table.
Meanwhile, the visitors to Energizer Park are in fifth position in the Eastern Conference standings, seven points adrift of the leaders.
However, Orlando City have lost two of their last seven games to give a glimmer of hope to opponents who have accumulated four points from their last three matches.
How the bookies see it: Orlando City priced too high?
That is reflected in the betting odds offered by BoyleSports with Orlando City priced at 11/10.
Those are curious given that Oscar Pareja's team have lost just two of their nine matches on their travels in this year's MLS.
However, St Louis City have lost just three times in nine such games at Energizer Park and have subsequently been priced at 7/4.
The draw is on offer at 5/2, an appealing price given that neither of these teams have been prolific in attack in their respective home and away encounters in 2025.
Head to head: Just the second-ever meeting
Given that St Louis City only started playing matches in 2023, there have only been one game between these two teams.
That came back in that year when Orlando City came through by a 2-1 scoreline at the Exploria Stadium.
Players to watch: The class to come from Klauss?
Only four of the St Louis City squad have netted more than once in MLS this season with Joao Klauss leading the way with five strikes.
However, it should be noted that four of those goals have been scored in his last three appearances, including a hat-trick in the 3-3 draw with Los Angeles Galaxy last time out.
Meanwhile, 21 of Orlando City's 32 goals in this season's MLS have been scored by either Martin Ojeda, Luis Muriel or Marco Pasalic.
Pasalic assisted Ojeda for his ninth of the campaign last time out, but the Argentine was ending a four-match streak by getting on the scoresheet.
Predicted lineups: Minimal changes for both?
Conrad Wallem could be brought back into the St Louis midfield for his first start since being sent off at the end of May.
Alfredo Morales is most likely to drop out of the team in what may prove to be the only alteration.
While Cesar Araujo is an option to be recalled in the Orlando City engine room, the Uruguayan may have to stay patient with the visitors likely to operate with a two-man attack.
Pedro Gallese, Rodrigo Schlegel, Robin Jansson and Eduard Atuesta are all one yellow card away from a one-match ban.
St Louis City: Burki; Totland, Hiebert, Baumgartl, Reid; Watts, Wallem; Becher, Hartel, Pompeu; Klauss
Orlando City: Gallese; Thorhallson, Schlegel, Jansson, Brekalo; Pasalic, Atuesta, Gerbet, Angulo; Muriel, Ojeda
Anything else catch the eye?
Orlando City have scored in their last seven MLS fixtures, accumulating 14 strikes during that period.
However, they have only netted more than once in one of their most recent four encounters.
St Louis City may have scored six times in three MLS contests, but they have been increasingly reliant on Klauss's goals.
Furthermore, St Louis City have not kept a clean sheet in nine matches, despite possessing the 10th-best defensive record in the Western Conference.
GambleAware