Plymouth Argyle and Luton Town both find themselves languishing in the bottom half of the EFL Championship table so will be looking to climb up a few places with a win at Home Park.
The Pilgrims dodged the drop by a single point last term but made a high-profile appointment in the summer by naming Wayne Rooney as their new manager.
The former England captain made a decent start in management under tough circumstances at Derby County but is looking to rebuild his reputation after ill-fated spells in charge of DC United and Birmingham.
Establishing Plymouth as a Championship club is the immediate aim but Rooney has taken just five points from his first six games, leaving Argyle hovering just a point above the drop zone once more.
Luton Town started the season looking to make an immediate return to the Premier League after suffering relegation yet stumbled out of the blocks, failing to win any of their first five games in all competitions.
They are now showing signs of turning things around, with wins over Millwall and Sheffield Wednesday in their last two outings, and boss Rob Edwards will be looking for another three points here to move up from 14th place in the table.
How the bookies view it: Luton revival to pick up pace
With Luton's form picking up of late, Betano make the Hatters odds-on favourites at 5/6. Plymouth Argyle are 13/5 outsiders and the draw pays 11/4.
Recent head to head: No home comfort for Pilgrims
These sides were both in League One when they last faced off in season 2018/19. It was Luton who came out on top in that campaign, following up a 5-1 win at home with a 0-0 draw on the road. The Pilgrims have a poor home record in this fixture, going four without a win since a 1-0 victory way back in 2006.
Players to watch: Morris drought of the doldrums
Carlton Morris drew a blank in his first six games this term but the Luton striker returned to form with a double in last week's win over Sheffield Wednesday. That will have boosted his confidence and he's 6/4 at Betano for another goal here.
I was surprised Plymouth managed to hold on to Morgan Whittaker during the transfer window as he had been attracting interest from a few clubs. The winger is 11/5 at Betano to net his second goal of the season while Unibet price him at a whopping 7/1 for an assist.
Probable line-ups
Plymouth Argyle look set to be without Ben Galloway and Darko Gyabi again while keeper Conor Hazard is a long-term crock. Tom Lockyer, Jacob Brown and Daiki Hashioka.
Plymouth Argyle: Grimshaw, Mumba, Szucs, Edwards, Gibson, Cissoko, Whittaker, Gyabi, Randell, Forshaw, Hardie.
Luton Town: Kaminski, McGuinness, Mengi, Burke, Walters, Nakamba, Krauss, Doughty, Adebayo, Chong, Morris.
Anything else catch the eye?
Plymouth's last home game was a thriller as they shocked leaders Sunderland to claim a 3-2, busting a coupon for the Betting Desk. Luton Town are usually good value in the BTTS market so it bodes well for a decent game.
Combining BTTS and over 2.5 goals pays 10/11 with Bet365 while over 3.5 strikes on its own is longer odds at 13/8. Four of the five strikes in that clash with the Black Cats came after the break so backing the second half for most goals also appeals at 20/21 with Bet365.
This England Championship match between Plymouth Argyle and Luton Town will be played on Sep 27, 2024 and kick off at 20:00. Check below for our tipsters best Plymouth Argyle vs Luton Town prediction. You may also visit our dedicated betting previews section for the most up to date previews.
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