A fortnight after their hard-fought 1-1 draw in Spain, Bayer Leverkusen and Real Betis reconvene in Europa League Group G on Thursday night.
The pair are still locked together on seven points in the section, with Leverkusen leading the way on account of their superior goal difference.
Gerardo Seoane's side have seen their blistering start to the Bundesliga season hit a bump in the road, with Die Werkself winless in five matches across all competitions.
The hosts preparations for their rematch with Real Betis were far from ideal, with Leverkusen suffering a 2-0 loss against Wolfsburg on Saturday, their third successive home defeat in a row
After recording 3-2 and 4-1 victories against Rayo Vallecano and Valencia, Real Betis were then brought back down to earth when being put to the sword by Spanish kings Atletico Madrid on Sunday.
Manuel Pellegrini is now tasked with lifting the Green-and-Whites' spirits in the dressing room ahead of Thursday's trip to the BayArena.
Outright Betting
Bayer Leverkusen are 66/67 (SBK) favourites to bank three points that would put them in pole position to win the pool.
The pair played out a stalemate in Andalusia two weeks ago and the same outcome here can be backed at 14/5 with SBK while a Real Betis triumph is trading 27/10 (SBK) with the same bookmaker.
Betting Angles
There isn't a huge amount of appeal in the 1×2 market here and backing both teams to score is too short to put up as an alternative at a general 4/7.
However, combining BTTS and each team to hit three or more corners will bring about an even-money (1/1) Bet Builder with PaddyPower that makes plenty of appeal.
There has been no shortage of goals in games involving either of these two teams this season and all signs point towards another entertaining match-up on the eastern bank of the Rhine.
All three of Real Betis' opening three Europa League Group G games have paid out for both teams to score backers, while two of Leverkusen's first three pool fixtures have seen both teams oblige.
What's more, collectively the pair have posted only five shutouts in their combined 23 domestic league outings this season to date, so backing both teams to get on the scoresheet at the BayArena seems a sensible solution.
In order to boost the odds and bring about the aforementioned even-money (PaddyPower) Bet Builder, I'll also side with each team to hit three or more corners in a game that should deliver a decent degree of goalmouth action.
The German hosts are averaging 5.7 corners per-game in the Bundesliga this season, while Los Verdiblancos are not too far behind with their 4.9 per 90 minute tally in La Liga this term.
With all that in mind, coupled with the fact that the same Bet Builder has banked in Betis' three Europa League outings so far, one of which was the reverse fixture, I'll happily support the same formula at the BayArena on Thursday night.
This UEFA Europa League match between Bayer Leverkusen and Real Betis will be played on Nov 4, 2021 and kick off at 20:00. Check below for our tipsters best Bayer Leverkusen vs Real Betis prediction. You may also visit our dedicated betting previews section for the most up to date previews.