Atletico Madrid v Osasuna
Atletico have been hindered by too many early-season draws as they bid to get their title defence back on track against Osasuna.
After three stalemates in their last four outings, Diego Simeone's men are four points adrift of Real Madrid and five below leaders Sociedad, who have played a game more.
Having squandered a 3-1 lead to draw away to Valencia in the final fixture before the international break, Atletico are back on home soil and desperate for victory against an Osasuna side who are handily placed in seventh but haven't won in four while losing the last two.
Back Atletico at 4-9 with Bet365.
Sevilla v Alaves
Another La Liga title hopeful, Sevilla, can go top of the table with victory over improving Alaves.
Sevilla's home form is superb, winning seven on the spin and 11 of the last 12.
Alaves have risen to two points above the relegation zone with a stellar run of three wins and a draw, but the trip to the Andalusian capital looks too tall an order. Take the hosts at 4-9 with Bet365.
Borussia Dortmund v Stuttgart
Dortmund are just about clinging on to the coat-tails of Bundesliga leaders Bayern Munich but need to bounce back quickly from defeat at Leizpig.
That ended a four-game league winning streak for Marco Rose's side, who should prove too strong for struggling Stuttgart.
The visitors have suffered back-to-back defeats and gone four without victory, so Dortmund at 1-3 with Bet365 is acca worthy.
St Gallen v Lausanne
St Gallen are improving their fortunes in the Swiss Super League thanks to a run of three victories in four, including the scalps of champions Young Boys and current leaders Basel.
Chasing a third straight victory, they host bottom club Lausanne who are in danger of being cut adrift with just one win to their name all season.
St Gallen can prevail at 4-5 with William Hill.
Euro Acca
- St Gallen (1.15pm)
- Borussia Dortmund (2.30pm)
- Sevilla (3.15pm)
- Atletico Madrid (5.30pm)
- (4-1, Boylesports)