Argentina have been underlining their status as the best team on the planet in South American World Cup qualifying and head into this clash with Chile having already booked their ticket to the USA and Canada.
This is a golden era for the Argentines, with Lionel Scaloni's side winning the last two Copa Americas and getting the monkey off Lionel Messi's back by romping to World Cup glory in Qatar.
They're showing no signs of slowing down and sit eight points clear at the top of the World Cup qualifying group with four rounds of fixtures still to play.
Chile find themselves sitting bottom of the 10-team section but all hope is not yet lost as they sit just five points off the pace for a play-off slot.
It's sad to see the Chileans propping up the pile as they were the best team in South America just a decade ago, winning back to back Copas in 2015 and 2016.
The new generation don't have the same class as the team that won so many admirers when Alexis Sanchez, Arturo Vidal and Eduardo Vargas were in their pomp.
They've won just two of their 14 qualifiers so far and fans heading to the game Santiago will going to the stadium in hope rather than expectation.
How the bookies view it: Chileans written off
Even though Argentina have nothing to play for, they are still heavy favourites for this one at 8/11 with BoyleSports. Chile are 15/4 outsiders and the draw pays 23/10.
Recent head to head: Argentina romping it
Argentina haven't lost inside 90 minutes in the last 14 meetings, with Chile's only victory during that run coming on penalties after a 0-0 draw in the 2016 Copa America. It ended in a 3-0 win for Argentina earlier in the group, with a scorer bet landing for our man Andy.
Players to watch: Alvarez on a roll
Julian Alvarez heads into this game after a stellar season at club level with Atletico Madrid. The forward has been scoring for fun so could be worth a punt for anytime scorer at 8/5 at Bet365.
Lucas Cepeda looks the best of the emerging Chilean talent, with the 22-year-old netting three times in just five caps. He's 15/4 for anytime score which looks a decent price if he starts.
Probable line-ups
Veteran forward Vargas is Chile's top scorer in World Cup qualifying but he misses out here after not being named in the squad. Fellow old boys Sanchez and Vidal could feautre though.
Scaloni has picked a strong squad, despite Argentina's place in the World Cup already being assured. Lautaro Martinez looked short of fitness in the Champions League Final so it would be a surprise if he started this one.
Chile: Cortes, Maripan, Diaz, Suazo, Echeverria, Pizarro, Vidal, Osorio, Valdes, Sanchez, Cepeda.
Argentina: Martinez, Tagliafico, Romero, Molina, Foyth, Paredes, De Paul, Fernandez, Messi, Mac Allister, Alvarez.
Anything else catch the eye?
Although Chile sit bottom of the pile, their record at home has actually been pretty decent in the World Cup qualifiers. They've only lost to Brazil and Bolivia at home, with both of those games ending in 2-1 scorelines.
With Argentina already through, their intensity could drop a bit so Chile might be worth a punt in the double chance at 21/20 with BoyleSports. The home side are also 13/8 in the one goal ahead market, which pays out if they take the lead.
We should see goals in this one, with BTTS and over 2.5 goals coming up in four of the last five at home for Chile. Combining those bets here pays 17/10 at BoyleSports while BTTS on its own is also decent at 20/21.
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