Welcoming Denmark to Estadio Municipal de Braga on Saturday, Jorge Jesus' Portugal will officially begin life without the most prolific goalscorer in international football history, following Cristiano Ronaldo’s retirement from the national team.
Despite the emotional weight of their captain's departure, Portugal enter the fixture in an incredibly strong position with four wins in four rounds and a guaranteed spot in the quarter-finals.
However, Jorge Jesus faces a significant squad reshuffle. Both Joao Cancelo and Francisco Conceicao will miss out due to suspension. Injuries have also taken their toll, ruling out Nuno Mendes and Rafael Leao.
Denmark find themselves in second place with six points following their two wins over Wales and the two heavy defeats against Portugal and Norway.
De Rod-Hvide are essentially fighting to protect their position and keep third-placed Wales at bay. However, they face defensive headaches on their own.
Andreas Christensen and Patrick Dorgu are out of the next couple of games, while Victor Nelsson is dealing with a shoulder injury.
Denmark have had problems on the road in recent times, with just three away wins in the last three full years.
How the bookies view it: No one has won in Portugal in years
Given Portugal's perfect record in the group and their impressive home record, bookmakers have priced them as strong favourites at around 1/2.
If you are seeking better returns, you can back Denmark at 19/4, while a draw is priced at 15/4.
Recent head-to-head: Portugal scored nine goals in the last two H2Hs
These two sides met just last month in Matchday 3, and it was the Portuguese who emerged victorious in a highly entertaining contest.
In fact, their last two encounters were absolute gems for neutral fans, with Portugal winning 4-2 and 5-2. This has been an ongoing theme in recent years, as Denmark lost five of the last six H2Hs.
Players to watch: Joao Felix thrives in the national shirt
With several creative players ruled out, Joao Felix will have to step up again. He was one of the reasons for Portugal’s success so far, as he scored in three of the four matches (A1).
Since then, he has also been very efficient for Al Nassr both in the domestic league and the AFC Champions League, recording three goals and seven assists in six appearances.
For Denmark, Rasmus Hojlund remains their most potent attacking threat. The Napoli striker hasn’t had the best season with Napoli so far, but has scored three times in the UNL for his country so far, including against Portugal last month.
Probable line-ups
Portugal: Costa, Nazinho, Veiga, Dalot, Dias, Vitinha, Neves, Fernandes, Felix, Ramos, Neto
Denmark: Hermansen, Maehle, Provstgaard, Andersen, Kristensen, Isaksen, Hojbjerg, Hjulmand, Hojlund, Daramy, Froholdt
Anything else catch the eye?
Portugal’s flawless home form should be enough to deal with a Danish side struggling for consistency.
The hosts simply have too much depth, even with a few notable absentees, and they have already proven they know how to dismantle Riemer's defensive setup.
Jorge Jesus has his side playing brilliant attacking football, and their perfect 12-point record speaks for itself.
Not to mention that, in recent history, there have been numerous occasions when they’ve looked significantly better without Cristiano Ronaldo, and he is now retired. The younger generation can now prove their worth.
With their quarter-final spot already secured and no real pressure, we can expect an open match with goals. The last two H2Hs in this competition produced six and seven goals, after all.
Portugal vs Denmark Betting Tips & Predictions
Further Reading
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