BOTH these cosmopolitan teams will be relieved to be back on Premier League duty after the rough and tumble of the FA Cup caused them plenty of headaches.
Wolves had to come from 2-0 down to salvage a replay against League One Shrewsbury before West Ham suffered even more against the side propping up the same division.
Wimbledon were well worth their thrilling 4-2 victory, forcing the Hammers to head back across London with red faces after a defeat that bust a few coupons.
They will be desperate to make amends at Molineux but seeing off Wolves in their own back yard is far from easy, as the likes of Manchester City and Liverpool can testify.
Nuno Espirito Santo's side have been one of the stories of the season and this match promises to be a cracker, with the sides very evenly matched. That lends appeal to the draw which is 13/5 with Bet365.
Wolves stopper Wily Boly serves the final game of a three-match suspension while the Hammers still have a lengthy injury list.
Lucas Perez picked up a knock in the Cup loss, joining the likes of Jack Wilshere, Andriy Yarmolenko, Winston Reid and Manuel Lanzini on the sidelines.
But the big boost for West Ham is that star striker Marko Arnautovic is set to return after deciding against a big-money move to China before signing a new deal.
The stage is set for him to return with a goal and the big Austrian is 13/2 to net first and 9/4 for anytime scorer with Boylesports.
I tipped Raul Jimenez to net in Wolves' last home game, only for the Mexican to be upstaged by Diogo Jota who scored a stunning hat-trick in their 4-3 win over Leicester.
That makes me side with the Portuguese livewire this time and Jota is 2/1 with a few firms to score at any time.
Games with these sides usually see a few goals so it may pay to back over 2.5 goals here which is sadly just evens with BetVictor. Both teams to score also looks a good shout but the odds aren't great at a best 4/5 with Sportingbet.
This English Premier League match between Wolverhampton Wanderers and West Ham United will be played on Jan 29, 2019 and kick off at 19:45. Check below for our tipsters best Wolverhampton Wanderers vs West Ham United prediction. You may also visit our dedicated betting previews section for the most up to date previews.