SEVILLA have made their trophy cabinet a second home for the Europa League silverware with five triumphs, all between 2006 and 2016, making them the most successful club in the competition's history.
Their campaign this season started in the qualifiers back on August 2 and their hectic schedule – they've already played 43 games in all competitions – is beginning to take a toll.
Sevilla still occupy a top-four La Liga place but have gone three matches without a win in all competitions and their away form this term is a real weak point. They've suffered four straight defeats on the road – including a 6-1 drubbing at Barcelona – and won just two of their last 14.
They can expect another torrid test against a Lazio side on a three-game winning streak. Filippo Inzaghi's men are having a decent season in Serie A, sitting seventh but just a point outside the top-four Champions League spots.
Lazio tend to be strong at home – their only defeat in 10 came in a last-gasp 2-1 loss to Juventus in a match dominated by the hosts. However, two major injury doubts are casting a shadow over the Italians' hopes heading into this first leg.
Star striker Ciro Immobile – whose 11 Serie A goals this season is a third of his team's total – is struggling with a thigh strain and playmaker Sergej Milinkovic-Savic may also miss out with a groin complaint.
The loss of those two key players would be a massive blow and severely dent the hosts' firepower. They could still sneak it against a Sevilla sit who'll be content to sit tight and play for a point with the intention to turn the tie around at home.
Lazio draw no bet pays 18-25 at Marathonbet while goals could be at a premium with leg-weary Sevilla having failed to score in three of their last four away trips.
Under 2.5 goals is 81-100 at Marathonbet but I prefer that doubled with Lazio double chance at 5-4 with bet365's Bet Builder.
It could be a cagey start as the teams suss each other out and a draw at half-time catches the eye at 107-100 with Marathonbet.
This UEFA Europa League match between Lazio and Sevilla will be played on Feb 14, 2019 and kick off at 17:55. Check below for our tipsters best Lazio vs Sevilla prediction. You may also visit our dedicated betting previews section for the most up to date previews.