LILLE already look also-rans in Group H but they can still have a major say in which two teams progress to the last 16.
They have already landed a damaging blow on Valencia, grabbing a 96th-minute equaliser a fortnight ago to deny the Spaniards a win which would have put them neck and neck with Ajax and Chelsea on six points.
If Valencia are serious about pipping one of those European heavyweights to a spot in the knockout phase then three points at home to Lille are a must.
Neither side head into this match in convincing form, however. Valencia languish 13th in La Liga where they claimed a first win in four matches with a come-from-behind 2-1 success at Espanyol on Saturday.
That will provided a much-needed confidence boost ahead of this crucial European clash, as will Lille's ropey away record.
The French outfit sit fifth in Ligue 1 but that is largely thanks to their home prowess. The 2-1 defeat at Marseille on Saturday extended their winless run on the road to 11 matches. That, coupled with Valencia's need for the points, should see the Spaniards edge this one at 20-23 with Coral.
Despite their travel sickness, Lille have netted in four consecutive away matches and Valencia's last six games have all had goals at both ends, so btts is a tempting proposition at 20-23 with Ladbrokes.
Spain international Daniel Parejo is an attacking midfielder who poses a real goal threat. The 30-year-old is Valencia's top scorer this season with six goals – four of which were penalties – in 15 appearances.
Parejo ended a three-game run without a goal by hauling his side level from the spot against Espanyol at the weekend and represents value at 16-5 with Unibet to net any time here.
It took until after the hour for the first goal when these sides met in France, and the 5-4 at Paddy Power for the opener to come after the 30th minute at the Mestalla seems decent with Valencia not exactly banging them in and Lille looking to keep things tight.
This UEFA Champions League match between Valencia and Lille will be played on Nov 5, 2019 and kick off at 20:00. Check below for our tipsters best Valencia vs Lille prediction. You may also visit our dedicated betting previews section for the most up to date previews.